It is constituted of successively more complex stages of classifiers (Figure 2).
This is not a trivial point as more complex staging systems such as the previously mentioned nomograms have not been widely adopted in spite of improved prognostication.
In other words, the novel TNMG staging system proposed does not create a more complex staging system but rather builds upon the existing AJCC staging system with improved reflection of the underlying biology and associated impact on survival.
(G) A more complex, later stage intravillar neoplasm, characterized by polarized neoplastic glandular columnar cells (arrow), multiple neoplastic glandular lumina in a cribriform pattern (two examples are indicated by arrowheads), and solid areas of nonpolarized cells (asterisks).
It is, therefore, natural to see whether a two-stage process or even a more complex multi-stage one can account for the human data.
The discussion then moves on to a more complex multi-stage, multi-scale stochastic decision problem in which periodic investment/policy decisions are made on a time scale orders of magnitude slower than that of operating decisions.
The discussion then moves on to a more complex multi-stage, multi-scale stochastic decision problem in which periodic investment / policy decisions are to be made on a time-scale orders of magnitude slower than that of operating decisions.
For CVD, the gradient in associations from hypertension to IHD to HF, provide an indicative health status of populations and the potential change in physical health across the CVD spectrum as populations go from a single cardiovascular disease (such as hypertension) to more complex end-stage conditions such as heart failure.
For the socio-economically deprived, the reasons for poor survival remain unclear, but are likely to involve more complex factors than stage at diagnosis and treatment.
In Section 4 we analyze the first-stage selling probability, and in Section 5 we explore the more complex dynamic second-stage selling probability.
