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Moreover, combining the methods may allow for the detection of different forms of selection (i.e. local adaptation and uniform directional selection through a species range) or increasing power to detect more complex selection histories, for example a selective sweep within a single population that can drive an excess of differentiation merely by reducing the level of intra-population diversity.
Similar to Eastough and Miller [ 9], this study does not correct for selectivity bias that would require a more complex selection mechanism than the single selection mechanism.
All tested strategies consisted of twelve runoff measurements within one year and ranged from simply using monthly flow maxima to a more complex selection of observation times.
Major concerns: 1) In the "protein evolution" experiment, a single cycle of mutation was done and it is not clear how more complex selection procedures would be implemented.
We note here that we have changed the title in line with suggestions from the reviewers and eLife editors to be, "Selection of chromosomal DNA libraries using a multiplex CRISPR system". 1) In the "protein evolution" experiment, a single cycle of mutation was done and it is not clear how more complex selection procedures would be implemented.
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Selecting a rectangle is interesting, but you might want to make more complex selections.
Good tight species might allow more complex hierarchical selection, which arguably might be how and why the tempo and mode of prokaryotic and eukaryotic evolution seem so different.
This finding supports those of other smaller scale studies that have shown the value of RNA dinucleotide models, albeit through more complex model selection criteria (Schöniger and von Haeseler 1994; Rzhetsky 1995; Tillier and Collins 1998; Savill et al. 2001; Telford et al. 2005).
Moreover, it typically serves as the basis for the development of more complex system selections.
Because measuring w max is much harder than measuring, L is more difficult to measure than V and our result provides a possibility for estimating L indirectly through V, by establishing the lowest L consistent with an observed V. Before, we considered connections between L, V, and selection differential in a more complex case of selection acting on a quantitative trait x [ 3].
We were also able to detect more complex patterns of selection within the loop, including a relationship between selection at three positions of the single stranded region, and differential selection of position 88 depending on whether the 88 94 base pair is intact.
More suggestions(15)
more complex contest
more complex process
more complex determination
more complex preference
more complex screening
more sophisticated selection
more complex choice
more complex recruitment
more complex choosing
more complex choices
more complex preparation
more relaxed selection
more expensive selection
more traditional selection
more complex picture
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