Therefore, in genetically unstable neoplasias with a poor prognosis we expect more complex chromatin remodeling, with many areas of varying optical density (alternating lighter and darker spots) and more irregular borders between them.
However, it is not clear whether this aberrant DNA methylation pattern is sufficient to determine gene silencing, or whether it is in fact part of a more complex process involving chromatin remodeling factors and changes in histone modifications[15], [16].
TGF β itself plays more complex role during bone remodeling, with the inhibition of Runx2 and osteoblast differentiation in vitro but mainly promoting bone formation in vivo [ 29, 32].
The effect on degree of mineralization may be more complex, since enhanced forces stimulates bone growth and remodelling [ 12, 39] and hence may increase the degree of mineralization, at least in young animals [ 10].
Danebury was remodelled several times, making it more complex and resulting in it becoming a "developed" hill fort.
With these caveats, there is still evidence that strain does play a role in bone remodeling, however, this role is more complex than originally thought [24] [26].
However, access to the target chromatic loci and remodeling by CRCs in vivo are more complex.
Diseases with a more complex pathophysiology, such as chronic hepatitis involving fibrosis and remodeling of tissue architecture, will be more challenging.
Many studies have demonstrated that interdigit regression is a more complex process than initially thought [ 5– 17], it includes massive apoptosis, growth arrest, and matrix remodeling of the interdigits [ 18].
Bankruptcy is more complex.
