The increase of genomic complexity is thus associated with a more complex regulation of gene expression since the additional genetic information has to be integrated into the existing regulatory network basically operating in a bacterial cell.
In three instances, a more complex regulation may exist, where an additional sensor or response regulator gene is adjacent to the pair, namely AB0416, AB0417, AB0418; AB0454, AB0455, and455; AB07950795, AB0796, AB0797.
miR* accumulation may also be developmentally regulated in the silkworm, which suggests a more complex regulation of miR and miR* sequences than was previously proposed.
It is also possible that these miRNAs and targets are regulated by other unidentified factors associated with a more complex regulation [ 52, 53].
Finally, being out of the EU might reduce market opportunities for UK companies, with fewer customers and more complex regulation to trade.
These results also point to a more complex regulation of COX-2 expression besides NF-κB (Inoue et al., 1995; Miller et al., 1998).
These results raise the possibilities that CCaMK plays a role in sorting the signals derived from AM or RN symbioses and that RN symbiosis requires more complex regulation of CCaMK through CaMBD/EF hand domains (Takeda et al. 2012).
Sometimes more than one enzyme can catalyze the same reaction in parallel; this can allow more complex regulation: with, for example, a low constant activity provided by one enzyme but an inducible high activity from a second enzyme.
As discussed, these are probably indirect or more complex regulation events.
This opens the possibility of a more complex regulation of cytoskeletal architecture by BMPs.
This indicates that unique intracellular pathogens such as M. tuberculosis might show more complex regulation of the expression of their rel operons.
