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As a capacity building and the first stage towards a more complex regimen, the safety and immunogenicity of MVA.HIVA vaccine alone is under evaluation in two phase I infant vaccine clinical trials in sub-Saharan Africa [12].
Furthermore, as a result of undetected or unreported therapeutic non-compliance, physicians may recommend a more complex regimen, which may increase costs and adverse events risks.
Therefore, once-daily DOAC therapy may be preferred to twice-daily therapy in patients in whom adherence with a more complex regimen might be a concern.
However, respondents would prefer to continue with the more complex regimen if there was a 20% decrease in the risk of future unwanted medication effects with the new medication relative to the old medication.
23 Further, these resistance mutations also often preclude simplification of a PI-containing or more complex regimen in a virologic-controlled patient because these mutations may be "archived" by the virus and become manifest during incomplete antiretroviral therapy.
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When complexity of the insulin regimen was taken into account, more complex regimens including adjustment for carbohydrate intake and blood glucose level were significantly associated with the DNT.
More complex regimens were related to decreased adherence, but were often successfully mitigated by regimen aids.
However, this needs to be weighed against the risk of decreased adherence if combination therapy for IPTi results in longer and more complex regimens (e.g. single dose SP versus 3 days of SP-AS3).
Another method might use more complex regimens, such as sequential therapies, to achieve successful eradication by lower bacterial load.
More frequent injection omission among individuals taking more injections could reflect the frequently reported finding that more complex regimens are associated with lower levels of adherence (6).
Non-adherence may be lower for more complex regimens, but significant non-adherence remains even when the frequency of dosing is reduced[ 36, 37].
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more religious regimen
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