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Other differences are likely to be attributable to interacting effects of the transporter used, the iron molecule imported, and other more complex primary and secondary responses, for example due to changes in major surface porins such as PorB and RmpM.
Genes with multiple ATI sites have longer 5′-grey areas and produce more complex primary transcripts with larger numbers of isoforms than genes with multiple ATT sites (supplementary table S5; supplementary fig. S2, Supplementary Material online).
In more complex primary or revision cases, some surgeons perform an osteotomy for better exposure of the hip; i.e. the existing anatomy can be prepared more adequately and the components can be removed and placed more precisely [ 1, 2].
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In a Scottish qualitative study from 1998, GPs were reported to be less clear about the evidence for statins in primary prevention than in secondary prevention, and found social and economic issues more complex regarding primary prevention [ 27].
These include identifying patients using existing clinical software, which uses single disease coding systems, the estimation of the process of care, and polypharmacy issues, all of which make management of these patients more complex for primary care practitioners.
Secondary legislation, or statutory instruments, are meant to be used for simple, non-controversial measures, in contrast to more complex items of primary legislation known as bills.
This analysis can be extended to the more complex case where primary control loops are abstracted into first-order transfer functions (Tucci et al., 2016a).
Numerous more flexible and complex primary models have been suggested but in most cases they have no advantage over the simpler primary growth models (Dalgaard, 2002).
However, the problem of bone involvement in RA and AS is more complex than in primary osteoporosis alone.
The additional implementation of guidelines and the use of more complex interventions in primary care yield a significant reduction in depressive symptomatology.
These more complex components of primary prevention of CHD cannot be expected of CMHTs, and therefore raise important questions about the level of CMHT involvement that is appropriate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com