Sentence examples for more complex mutations from inspiring English sources

To quantify AI at each position in the genome, our method first tallies di-colors from reads aligned to that position that represent either a reference nucleotide or a single nucleotide substitution, filtering from further analysis invalid di-colors, which likely represent sequencing errors or more complex mutations.

More complex mutations such as insertion/deletion/nonsense are also described.

These more complex mutations are predicted to affect the north and south interfaces, respectively, and their combination abolishes dimer formation [21].

The 1000 Genomes Project used next generation scanners to identify 15 million single base changes (SNPs) and more complex mutations [ 3, 4].

Therefore, we have incomplete data to calculate the precise contribution of mutations in different PD genes together with an underestimation of more complex mutations like CNVs.

Thus, more complex mutations such as insertion of several nucleotides adjacent to codon K294 that mediate strong resistance might require genetic instability as it is present in blast crisis.

Our results indicate that Chinese FA patients and carriers might have higher and more complex mutation rates in FANC genes than have been conventionally recognized.

ChrX's mode of inheritance entails different phenotypic consequences of X-linked polymorphisms, including the exposure of recessive mutations in hemizygous males, a higher chance of dominant mutations affecting females, and more complex mutation models [ 14, 15].

Indeed, the emergence of drug resistance has been a major threat to the sustained effectiveness of cART in resource-rich settings [ 9] and the continuation of a failing regimen may be associated with more complex mutation patterns as observed in several studies [ 10– 10].

In this article, we analyze this evolutionary choice between immediately beneficial mutations and more complex mutational trajectories that ultimately lead to higher fitness.

On rugged fitness landscapes where sign epistasis is common, adaptation can often involve either individually beneficial "uphill" mutations or more complex mutational trajectories involving fitness valleys or plateaus.