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Inflammatory chemokines, interleukins and TNF- α can be classified as either pro- or anti-inflammatory biomarkers, but some have more complex, multifunctional roles such as TNF- α, TRAF6, IL-1 β and IL-6.
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Farnesyltransferase inhibitors were initially designed to inhibit the post-translational modification necessary for Ras activation (Kato et al, 1992), but their mechanism of action seemed to be more complex involving also other multifunctional proteins (Prendergast et al, 1994; Sepp-Lorenzino et al, 1995; Maltese, 1998; Du and Prendergast, 1999).
These structures pave the way for a more complete understanding of these complex, multifunctional machines which are also targets for anti-viral drug design.
The high control opened the possibility to construct more complex polymeric structures, exemplified via the synthesis of a multifunctional triblock copolymer composed of AOMEC as the center block, flanked with a statistical copolymer consisting of ɛCL and αBrγBL.
These polymers represent unique yet easily and economically available multifunctional nanoscopic dendritic building blocks for more complex 3D nano-structured materials for a variety of applications in electronics, photonics, lithography, specialty coatings, etc.
More generally, it is naïve to attribute the emergence of a highly complex, multifunctional cellular machine like the nucleus to a single selective factor.
The more complex and the greater the need for longevity in vertebrate evolution, the more common and multifunctional these protein cascades become.
With this goal, magnetic materials, highly conducting and metallic single-component materials containing dithiolene complex building blocks, multifunctional materials where the dithiolene complex is the magnetic or conducting component in addition to more complex systems involving other types of building block such as the metal oxalate complexes, will be discussed.
Since both IL-6 and MIP-1α are multifunctional proteins, it is difficult to know if their biological roles are purely inflammatory, or more complex.
A wealth manager's daily work is similar to that of an architect, in that both design complex, multifunctional structures.
Bankruptcy is more complex.
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CEO of Professional Science Editing for Scientists @ prosciediting.com