Sentence examples for more complex microenvironment from inspiring English sources

The data obtained were from experiments based on HIBECs cultured in vitro; thus, as a more complex microenvironment in vivo, whether blocking TACE or EGFR inhibits MUC5AC overexpression in bile ducts in vivo requires further study.

However, cells residing in their in vivo niches experience a far more complex microenvironment than those maintained in conventional cell culture; they interact with neighboring cells, the extracellular matrix (ECM), and with soluble factors present in the microenvironment.

Mixing multiple cell types and multiple extracellular matrix components allows the generation of even more complex microenvironments within the modules.

Experimental validation of these predictions should facilitate even more sophisticated and experimentally informed modeling efforts in the future, which may both lend greater insight into the underlying biological problem and permit simulations of cell migration in more complex microenvironments that better approximate the in vivo setting.

14 Taken together, these data are consistent with a more complex tumor microenvironment angiogenic network in the primary tumor than in the metastases.

Microtechnologies and bioreactors have resulted in the production of more complex cellular microenvironments, enhancing the functionality of engineered tissues.

Materiomics, which allows high throughput testing of complex material surfaces for specific applications, provides the necessary information for producing more complex cell microenvironments [ 167].

Therefore, the assumptions for extrapolation of such results to the disease process would be similar but our model would afford a more complex and representative microenvironment.

Since no elongated branching ductal structures are formed in the orthotopic site to enable the outgrowths to fill the mammary fat pad, it appears that the Py230 cells are capable of forming branching ductal structures under certain conditions in vitro, with these structures being limited in length in the more complex in vivo microenvironment.

This view has now been extended to include whole pathways and a more complex relationship with the microenvironment of the cell [ 38, 39].

A new line of evidence suggested that in skeletal muscle the perivascular compartment represents a complex microenvironment, with more elaborated functions.