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The usefulness of moving from simple frequency counts to a more complex methodology cannot be illustrated with a better example than the groundbreaking work on extending the simple "citation and backlinks to a webpage" method into a more informative measure, namely Google's PageRank [3].
A more complex methodology was used by Borchers et al. (2013) for the invalidation of models and for parameter estimation.
MTC meta-analyses can be conducted using more complex methodology, often employing Bayesian approaches, to compare multiple interventions.
The substrate did not only enhance the protection of probiotic bacteria; but it was also a more complex methodology than direct addition of lyophilized culture.
Some limitations of the above approaches include increased sample preparation time, more complex methodology and higher costs attributed to labelling reagents (Wang et al, 2008).
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Various methods have been published to investigate the bioaccessibility of Pb particles in environmental media, using simple to more complex methodologies aimed at reproducing to a varying extent the conditions in the digestive tract to which the particles are exposed.
In industrialised countries, measuring efficiency, benchmarking and consequent improvement of performance have become a standard and a wide variety of instruments was developed, ranging from simple ratios and unit costing to more complex methodologies, such as Data Envelopment Analysis DEAandand Stochastic Frontier Analysis [8].
Moreover, more complex methodologies which take into account network distances – the distance to an outlet based on road and footpath measurements – can be adapted to explore these relationships.
Consideration of these remote indirect effects requires more complex methodologies for CEA in DI compared to CEA in therapeutic services [ 16].
More efforts and funds must be directed to R&D on NHPs where a more complex research methodology should be carried out as compared to synthetic drugs.
While the views of the students are obviously important, these are presently being investigated using a more complex study methodology comparing two different student groups.
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