However, it must be noted that the results we present here will impact other analyses including inferred relative changes derived by comparisons to a reference sample, through more complex loop designs, or from comparisons between single-color assays such as those which are commonly performed using the Affymetrix GeneChip™ or filter array platforms.
Whether poverty "is caused by dysfunction, or the dysfunction is itself a product of the poverty, or, as is likely, the dysfunction and the poverty interact in ever more complex feedback loops, for the larger community to wash its hands of the problem represents an extraordinary failure of the moral imagination".
p53 is engaged in a number of positive and negative feedback loops to regulate carcinogenesis, aging and other biological processes [ 33]. p53 and MDM2, which is a p53-induced E3 ubiquitin ligase and targets p53 for ubiquitination and proteasomal degradation, form a minimum feedback unit that takes part in several larger and more complex feedback loops.
Further, NMA can compare more complex network loops (figure 2). Figure 2 shows that comparative effectiveness among the ICS' X, Y and Z can be estimated by combining direct evidence (effect B-C) and indirect effects using drug A and placebo as common comparators.
As it consists of multiple control loops with different characteristics (reactive, deliberative and reflective) urgent tasks can be a less complex control loop (e.g., a reactive variant) and iteratively improved later on by a more complex control loop (i.e., a deliberative or reflective control loop).
The binaural structure is characterized by a significantly more complex closed-loop system, possibly with multiple microphone inputs, but most importantly with two connected LS outputs, which considerably complicates the analysis of the system.
Since cleavage is independent of DNA topology, we can also rule out more complex DNA looping [ 10], as seen with supercoiling-dependent site-specific recombinases [ 15].
More rarely, the tips of non-adjacent thylakoids from the same stack were connected by more topologically complex looping structures.
They are a minimal representation of the regulatory principles, potentially representing overall effects of more complex, indirect regulatory loops.
Simulations results suggest that the novel SMC-based oscillator offers an advantageous alternative to more complex phase-locked loop (PLL) architectures, traditionally used for the driving of MEMS resonator structures.
