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Model 44 involves Hill Kinetics and model 143 even more complex kinetic laws; so our approach cannot guarantee the uniqueness of the structure for these two cases.
It is suggested to take these processes into account in a more complex kinetic equation for the reactions involved.
The reason why the kinetic law is different is that the reactions in the forward and reverse directions may occur by stepwise mechanisms that lead to a different and usually more complex kinetic equation.
Attempts to eliminate the strongest of the Alt X pairings by rational design of a quadruple mutant only resulted in more complex kinetic behavior.
More complex kinetic models requiring computer simulation of all the steps of adsorption, desorption, diffusion and exchange simultaneously have been developed.
Bench reactor data described in this work using a model Pt/Ba/Al2O3 NSR catalyst provide additional evidence in support of a more complex kinetic model of NOx storage.
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In this case a much more complex cubic kinetic scheme would be more appropriate than Figure 8.
In other cases, folding is more complex, and kinetic traps (low-energy wells or high-energy barriers) must be overcome before folding is complete.
However, more complex SHAPE kinetic patterns are observed for several other nucleotides, most of which show an increase of SHAPE reactivity at earlier time points followed by a gradual decrease.
While diagnostic studies in oncology commonly use the semiquantitative standardized uptake value, a single static measurement [ 5, 6], metabolic research questions generally require more complex tracer kinetic modelling approaches or graphical analysis [ 1, 7, 8].
Other software tools have been developed in the field (PopED, PopDes, POPT, and PkStamp), and a comparison of the results for design evaluation in a PK example and in a more complex pharmacokinetic/viral kinetic model was recently performed.
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