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However, recent studies have revealed that Mtb developed a more complex host immune response [ 26].
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The solution can be part of a more complex hosting structure as sub-component or it can be the whole structure itself.
The picture is likely to be more complex where host populations are better adapted because of higher host mutation rates.
In this work, we investigated whether the simple and facile D. melanogaster model can predict the outcome of infections in the more complex mouse host.
In the laboratory they provide a unique model to investigate how a simple eukaryotic cell can direct gene expression and induce proliferation of another, more complex, eukaryotic host cell.
We presume that the more complex a host's recognition signature is, the more difficult it becomes for distantly related organisms to evolve the appropriate biosynthetic pathways for the production of the essential recognition cues and to express the compounds in the correct relative proportions (even if key regulatory enzymes are involved).
The discovery of a genetic polymorphism in the interleukin 28B (IL28B) region on chromosome 19 of HCV patients depicted a more complex virus-host interaction.
Deletion reduces the HR symptoms in grapefruit and sweet orange, but doesn't increase the host range of the strain indicating a more complex determination of host range.
Since that time, effective antifungal compounds have been developed, but a much more complex array of host disorders have also emerged creating an even greater need for immunotherapy in conjunction with conventional antifungal therapy.
Targeting multiple host regulatory pathways through a single effector molecule would allow bacteria to more efficiently modulate complex host signaling networks and finely tune a specific environment for their lifestyle.
The European ecosystem is slightly more complex, involving two host species at about the same rate, the larger Leptothorax acervorum and the smaller Leptothorax muscorum, parasitized by the slavemaker Harpagoxenus sublaevis.
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