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However, our results do not rule out more complex guidance mechanisms that could modulate how pollen tubes follow a gradient based on some memory of previous concentrations or gradients [ 38].
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Cell transplantation therapies for photoreceptors demonstrate integration and restoration of function, but transplantation into the ganglion cell layer is more complex, requiring guidance of axons from transplanted cells to the optic nerve head in order to reach targets in the brain.
More complex cases usually require professional guidance to help a person heal from a specific trauma, treat sexual aversion or tackle phobias that may not be specific to sex, but may strongly influence sexual desire, such as a fear of germs.
As stated in the FDA guidance, the more complex designs are less understood which may impact the assessment of ethical perspectives.
In this background section we provide selected examples of organizations that have specifically provided information relevant to the key questions we posed although the WHO is unique in that its mandate includes the more complex task of providing international guidance.
These and other studies raised the possibility that SDF1/CXCR4 signaling in axon guidance might be more complex than that of the classic chemokine signaling pathway.
2. However, we may posit that for clinicians who do not receive any form of performance bonus like Trust chief executives, their motivational reasons for complying with NICE guidance may be more complex.
Subsequent guidance documents were far more complex as they each dealt with services for groups of cancers rather than single diseases (e.g. gynaecological malignancies).
The scores can offer theoretical guidance for astronaut training and more complex operation missions.
Parental guidance is also recommended for the more complex projects, making for a great opportunity to bond with kids through creation with a side of frustration.
Notably, this topography-induced guidance effect was also observed in more complex cell culture systems, such as the organotypic culture whole dorsal root ganglia (DRG) explants.
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