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Patients like Elsie Carter, who has been infected for at least 15 years and has already suffered several infections because of her weakened immune system, must follow more complex drug regimens, and their prognosis is worse.
There is a need to explore more complex drug interactions and their association with adverse events.
Second, more complex drug regimes are constantly emerging which may pose new challenges.
Furthermore, an increase in polypharmacy and more complex drug treatment regimens [ 21] may explain the lack of reduction in time consumption despite improvements in search capability.
Importantly once-daily dosing may be of particular benefit to older patients in whom adherence to more complex drug regimens may be more difficult.
However, it is widely considered that an increasing focus on three-dimensional structures, which incorporate a greater proportion of sp carbons, is probably desirable, 1 in order for medicinal chemistry programmes to be successful against more complex drug targets.
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Experts caution that this golden era won't last forever — many of the newer, more complex drugs coming on the market will be more difficult to copy cheaply, and fewer big drugs are set to lose their patent protection in the coming years.
These findings indicate that the sensitivity to PIM inhibitors is not directly correlated with the expression level of the kinases but might be driven by more complex drug-resistance associated mechanisms.
And Synthon Chiragenics, a drug-discovery company in Monmouth Junction, New Jersey, exploits carbohydrates such as lactose and starch abundant, freely available and notoriously chiral as building-blocks for more complex therapeutic drugs.Dr Sharpless goes even further.
Drug prescribing and administration is more complex in children: drug doses need to be calculated on an individual basis taking into account gestation and postnatal age, weight and/or body surface area [ 7, 8].
The pharmacokinetics and in vitro/in vivo relationships of transdermal (systemic drug administration) and topical (locally acting) drugs, are more complex than for oral drug products.
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