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We illustrate both the use of simple DNA artworks for sensing, computation, drug delivery and the application of more complex DNA architectures as scaffolds for the construction of protein and nanoparticle arrays.
Hundreds if not thousands of researchers have worked on the problem for fifty years, and for the last decade have had large databases to help; yet, in the words of a review published a few months ago in Science, "no single group [of researchers] yet consistently produces accurate models," especially with more complex DNA sequences that don't closely resemble genes that are already well understood.
Retroviruses have the potential to acquire host cell derived genetic material during reverse transcription and can integrate into the genomes of larger, more complex DNA viruses.
Therefore, structural studies of the archaeal system could be beneficial to understand the more complex DNA replication mechanism of eukaryotes.
The main focus of the present study was on the detection of small amounts of specific DNA sequences in more complex DNA mixtures.
The knowledge gained in insects can then be tested for its evolutionary conservation in organisms with a more complex DNA methylation landscape.
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In the following, a more detailed quantitative evaluation is conducted based on more complex DNAs. Figure 13 shows a DNA that makes the vehicle self-balancing, e.g., a Segway.
In contrast, the second category (type II TLR9-expressing cells) includes primarily follicular B cells in mice (and possibly colon epithelial cells and naïve B cells in humans) that directly respond to single stranded CpG-DNA, whereas they require additional co-signals to gain responsiveness to more complex CpG-DNA.
The first category (type I TLR9-expressing cells) includes myeloid and pDCs, macrophages and MZ-B cells in mice, and pDCs, MZ-B cells and memory B cells in humans, which can respond directly and without priming to both single-stranded and more complex CpG-DNA structures.
Tobacco smoke is another external source of DNA damage, but it leads to a more complex array of DNA damaging agents and lesions than UV does [ 5].
However, other explanations are also plausible, three of which are: (i) flavonoids interfere with DNA repair; (ii) flavonoids can have a more complex interaction with DNA damage, not based on repair induction; and (iii) flavonoids can interfere with the induction/selection of chromosome instability or bulky DNA adducts by carcinogens.
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CEO of Professional Science Editing for Scientists @ prosciediting.com