Additional large-scale population-based analyses addressing more complex disease determinants of obesity and diabetes (beyond single genetic polymorphisms) might improve understanding of the relative impact of genetic and environmental factors linking them.
This well-defined system highlights the different challenges between rendering a linear determinant (here) immunogenic, compared to applying this approach to a more complex conformational determinant such as the CD4 binding site of gp120 (recognized by the broadly neutralizing antibodies b12 and VRC01).
With in vitro studies, one can precisely delineate the mechanism of a putative virulence factor in a cellular phenotype of interest, but these studies are unable to assess the effect of a virulence determinant on more complex intercellular interactions.
17 From an aetiological perspective, we acknowledge that variables such as ethnicity or population density are likely to be markers for a suite of more complex, interactive social, genetic and environmental determinants of psychosis.
The reviewers asked how we can draw the conclusion that aa 381-395 is a ciliary targeting determinant and that our data suggest that the ciliary targeting determinant is a more complex or extended structure.
Unlike other gram-negative pathogens, diphtheria, tetanus or Hepatitis B virus, the pathogenesis of B.p is much more complex because a range of different virulence determinants have been implicated [8].
At these levels, determinants of ATM become more complex and intricate.
However, such a determinant constraint is substantially more complex than the corresponding linear constraint in (P3).
Findings show that determinants of home cooking are more complex than simply possessing cooking skills, and that potential positive associations between cooking, diet and health require further confirmation.
While undernutrition and excess adipose tissue - or overweight and obesity - can be reduced to a conceptual imbalance between the number of calories consumed and the number used by an individual, the determinants of bodyweight are much more complex.
Determinants of behaviour here are more complex and are driven by less overt illness and the mediators of change enacted.
