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Since discrete clusters are not necessarily the predicted product of other, more complex, demographic processes (e.g. isolation by distance or progenitor-derivative relationships), we have not modeled those important scenarios here, and leave them for future studies.
The data from the three surveyed non-African populations (French Basque, Chinese Han, and Melanesians) are inconsistent with the simple growth model, presumably because they reflect more complex demographic histories.
The assumption made here, that individuals mix nearly homogeneously out of their household may be an appropriate approximation for describing transmission within a neighbourhood or even a city [20], but ultimately one should also consider developing the estimators for more complex demographic situations such as a hierarchy of organisations (household, to village, to region, to country, etc).
This new method has significantly fewer model assumptions and allows us to identify more complex demographic processes, such as multiple admixture events.
Although the model of Zeng and Charlesworth (2009) could be further extended to incorporate more complex demographic models, this would introduce more parameters.
Through simulations, Yang et al. (2014) described the relationship between the projection and the derived allele frequency for more complex demographic models.
Similar(42)
More complex demographics such as a phylogenetic tree structure have been studied but generally under a small set of selective conditions [ 10- 12].
It would also be instructive to perform simulations with more realistic and complex demographic models to understand the limitations of StructHDP.
Florida's political life has become more complex with the massive demographic changes.
The algorithm we present for simulating genealogies influenced by positive selection will allow for more thorough exploration of complex demographic scenarios when evaluating methods for detecting positive selection.
Examination of ancient sequences in the domestic species might reveal a more complex pre-domestication bottleneck demographic history than the apparent constant population size shown here.
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