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As protocol designs become more complex, clinical trial durations and budgets increase.
Comorbid post-traumatic stress disorder (PTSD) and substance use disorders (SUD) commonly co-occur and is associated with a more complex clinical presentation with poorer clinical outcomes when compared with either disorder alone, and untreated PTSD can predict relapse to substance abuse.
Connectivity and data integration may allow the development of controllers able to process multiple parameters at the same time and hence guide or unload clinicians in more complex clinical situations.
MDT discussions were of more value for patients with more complex clinical problems.
Such patients have specific health care needs [ 38], require more complex clinical management and incur higher health care costs [ 44].
Simple risk algorithms have performed well in comparison with more complex clinical evaluations in studies of diabetes and cardiovascular disease.
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While the imaging of disease becomes ever more complex, the clinical conditions remain mainly unchanged although the ability of the clinical specialist to treat these conditions is advancing.
Policy initiatives are arguably even more complex than complex clinical interventions.
Therefore, we had to assume that the occurrence of an adverse event was independent of the presence of another, although this might be more complex in clinical reality.
They are also more complex in clinical terms, associated with greater genetic heterogeneity (Table 2) with an onset of symptoms that is generally early.
Others argued that they would like to have experienced a more complex, infrequent clinical scenario because they believed that would have encouraged greater learning (box 7, quotations 4).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com