Sentence examples for more complex chromatin from inspiring English sources

In eukaryotic cells, however, chromosomes are linear and DNA is folded into more complex chromatin fibres.

To this aim, we specifically focused on Patient 3, who had displayed the lowest reactivity to Valproic acid, thus potentially suggesting a more complex chromatin structure.

A more complex chromatin structure, less heterochromatin and a less perfect self-organization of the nucleus are expected in more aggressive neoplasias.

In general, a more aggressive behaviour is usually found in genetically unstable neoplasias with a higher number of genetic or epigenetic changes, which on the other hand, provoke a more complex chromatin rearrangement.

Therefore, in genetically unstable neoplasias with a poor prognosis we expect more complex chromatin remodeling, with many areas of varying optical density (alternating lighter and darker spots) and more irregular borders between them.

A more aggressive behaviour is usually found in genetically unstable neoplasias with a higher number of genetic or epigenetic changes, which provoke a more complex chromatin rearrangement, revealing an increased number of darker and lighter areas.

Alternatively, combinatorial interactions that rely on reader domains and generic or site-specific targeting activities may be exploited to regulate and achieve more complex chromatin-binding patterns and functionality.

Given the relatively similar DNA-binding specificities of all the ETS-family members, an important question is whether the specificity of binding comes from the observed relatively small differences in protein DNA binding affinity, or whether direct protein protein interactions, or more complex chromatin-mediated effects dominate.

However, it is not clear whether this aberrant DNA methylation pattern is sufficient to determine gene silencing, or whether it is in fact part of a more complex process involving chromatin remodeling factors and changes in histone modifications[15], [16].

It has been proposed that gene lengths indicate regulatory complexity (Vinogradov 2004, 2006a, 2006b): according to this theory, longer introns represent greater amount of regulatory sequences within them, required for more complex regulation and chromatin-mediated suppression of these genes.

In particular, the greater amount of intra- and intergenic noncoding DNA may be involved in the more complex regulation and chromatin-mediated suppression of these genes, whereas the greater length of coding sequences is likely to be related to more complex protein functional domains.