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The researchers said that more complex cells would present significant challenges.
From our group's experience building a whole-cell model of Mycoplasma genitalium, we identified several significant challenges to building models of more complex cells.
The third branch is eukaryotes, organisms with more complex cells that comprise the higher forms of life, up to humans.
The incorporation of smaller cells within larger ones resulted in the development of yet more complex cells called eukaryotes.
The seminal work of Hubel and Wiesel [ 3] showed that neurons in the primary visual cortex have receptive fields tuned to a variety of image features, from simple cells sensitive to local orientation in an image, to more complex cells capturing in addition, motion and length of local image features.
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Our aim is to highlight that non-classical TNFR-TNFL dyads such as the LT system demonstrate more complex, cell-type and context-specific capabilities.
Notably, this topography-induced guidance effect was also observed in more complex cell culture systems, such as the organotypic culture whole dorsal root ganglia (DRG) explants.
How human endothelial cells can be usefully incorporated into more complex cell culture models is presented as an example of how relevant questions in tissue engineering and regenerative medicine can be addressed.
"A lot of our collaborators are trying to make in vitro systems more reflective of real biology," which often requires using more complex cell-culture systems, says Carpenter, who is now leading a computational biology group at the Broad Institute of MIT and Harvard in Cambridge, Massachusetts.
However, while this is an intriguing possibility, further more complex cell biological studies would clearly be needed to provide direct evidence of this hypothesis.
Moreover, the effect of receptor drifting on the cell surface, the differential receptor recycling in different parts of the cell and more complex cell morphology can be considered to further develop the model.
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