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14 However, significant hurdles still exist in modelling the more complex cardiovascular diseases using iPSC technology.
In contrast, the present study also included high-risk patients subjected to more complex cardiovascular surgery in elective and non-elective settings.
18 Until such methods are optimised and further research is performed in the area of maturation of iPSC-CMs, modelling of the more complex cardiovascular diseases including the cardiomyopathies will remain a major challenge.
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Our report builds on previous pharmacovigilance studies of more complex outcomes such as cardiovascular disease, cerebrovascular disease, and gastrointestinal bleeding.
To reduce falls in older people, exercise programmes need to safely incorporate a challenge to the balance system [ 22- 24], which requires substantially more complex movement combinations than cardiovascular or strength training exercise programmes.
In order to overcome this we conducted an additional more complex analysis, including interactions between the specific cardiovascular conditions and the cardiovascular medicine count.
However, recent observations indicate a more complex role of both receptors in cardiovascular pathologies, which still need to be further elucidated [10].
These observations provide important new information about how vascular cells sense pathogens and danger signals, which may well have direct relevance to our understanding of cardiovascular disease in more complex settings.
Multiple reasons likely underlie the marked association between severe CKD and poor outcomes, including a greater number of cardiovascular risk factors, more complex coronary anatomy, increased overall atherosclerotic disease burden, and lower frequency of PCI and other recommended ACS treatments during hospitalization and follow up in patients with CKD [ 26- 28].
It contributes to the management of the various therapeutic dimensions which became increasingly more complex with the need to treat all cardiovascular factors.
Does it work equally across all dimensions of care – from simple recording of cardiovascular risk factors to more complex areas of care such as glycaemic control?
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