Sentence examples for more complex alterations from inspiring English sources

This can involve basic changes, like language translation, to more complex alterations, such as modifying sexual images to adhere to cultural norms.

Simple mutations are fed through Mutation Checker (Stajich et al, 2002) before being imported to COSMIC, while more complex alterations are manually annotated.

We therefore suggest taking into account the occurrence of rare KRAS gene substitutions or more complex alterations for a more accurate patient selection for anti-EGFR therapies.

To investigate secondary drug effects, wild-type yeast strains were exposed to higher doses of FK506 and CsA, leading to much more complex alterations in microarray expression profiles.

And, we defined indels simply as the presence or lack of a protein coding sequence at a specific location; other more complex alterations, such as deletion of untranslated regions, SNPs or inversions, were not tabulated.

In many cases, oral medicines are modified to ease administration in these patients, ranging from simple removal from packaging to dispensing in a dosette box, to more complex alterations including crushing or splitting of solid oral dosage forms [ 2– 6].

49– 52 These pathological anatomical alterations underline a more complex modification in neurotransmission resulting in a reduction of the cholinergic transmission.

This study was initiated to investigate whether CNVs were associated with acquisition of more complex genomic alterations in CML.

However, the role of GDF5 seems much more complex and alterations of its function might also affect other tissues of the joint.

The label-free MS analysis presented here could show that, in contrast to the characteristic slow-to-fast transitions associated with disuse-related muscular atrophy or denervation-associated fibre wasting, motor neuron disease exhibits more complex protein alterations on the level of metabolic enzymes and contractile proteins.

Taken together, our data reveal more frequent and complex alterations of ETS genes than previously recognized and identify key genes like EZH2 and Nkx3.1 contributing to the reprogramming of prostate epithelial cell transcriptome in response to aberrant expression of oncogenic and tumor suppressor ETS factors.