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However, when more complete suppression of protein synthesis was produced by infecting the cells with the Δγ34.5 mutant, which is incapable of reversing the host-induced shut-off of protein synthesis, APP-F35 and APP-F45 formation was almost completely abolished.
Its superior efficacy might be due to better inhibition of whole-body aromatisation and more complete suppression of plasma and intra-tumour oestrogen levels (Geisler, 2011).
More complete suppression of M protein levels may be correlated with more complete reduction of the myeloma cell mass and with longer survival (Bross et al. 2004).
One possibility is that more complete suppression of the SlCOBRA-like gene by RNAi in culture tissues than resulting from CS may have caused lethality in early development.
Recently, several aspects of this paradigm have been challenged, including consideration for CNS-specific effectiveness into therapeutic decision making, the role of inadequately treated peripheral reservoirs, and the potential need for more complete suppression of inflammatory pathways.
Using a monoclonal antibody with greater affinity for IgE than omalizumab, we examined whether more complete suppression of IgE provided greater pharmacodynamic effects, including suppression of skin prick responses to allergen.
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Another study conducted in 54 postmenopausal women with invasive breast cancer showed that more complete inhibition of aromatase was achieved by 2.5 mg of letrozole than 1 mg of anastrozole, resulting in significantly greater suppression of estradiol (P < 0.0001) [ 15].
A recent study has demonstrated that the more complete inhibition of aromatase achieved by 2.5 mg of letrozole than by 1 mg of anastrozole results in a greater degree of suppression of estradiol [ 19].
The added level of inhibition onto VG3-ACs compared to conventional pathways through bipolar cells likely contributes to the more complete surround suppression in the OMS circuit.
These data support previously published reports showing that women over 40 years of age may achieve more complete estrogen suppression [ 5– 8].
The rates of oestrogen suppression achieved with aromatase inhibitors in obese patients were very high (about 98% for letrozole and 96% for anastrozole) and similar to those obtained in thin patients (Ligibel and Winer, 2012), thus suggesting that higher than standard doses of these drugs in obese women are unlikely to lead to a more complete oestrogen suppression.
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