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It is possible that the early depolarization is only partial and less radical than a more complete loss of membrane potential secondary to cell death much afterwards which causes the contradictory reports.
Reflecting differential effects on mTORC1 signaling, the TSC2-5A mutant renders a more complete loss of S307 phosphorylation and downshift of the IRS-1 protein than wild-type TSC2 or the TSC2-2A mutant.
Moreover, on more complete loss of let-7 or general miRNA activity, animals die by vulval bursting at the L/A transition.
And, a more complete loss from cells exposed to 500 μM FAC correlated well with the proliferative block seen at that concentration.
To obtain a more complete loss of Aplnr activity, we employed morpholinos (MOs) to inhibit aplnrb along with its paralog aplnra (Tucker et al., 2007).
Furthermore, they suggest that different degrees of BMP pathway inactivation may result in distinct phenotypes with partial loss of BMP pathway activity causing ISC overproliferation whereas more complete loss of BMP signaling leading to ISC loss.
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Because the RRK461 insertion appeared to be the more complete loss-of-function, we performed our subsequent analyses in that line unless specifically noted.
As with the more complete loss-of-function BRCA2 mutants, fibroblasts from the BRCA2 Tr / Tr embryos show poor growth kinetics and high levels of p53 and p21.
Whether such a strategy will lead to more frequent complete loss of HLA expression remains to be seen.
The number 1 for the loss of more than 0.7 m3/h (complete loss).
It is very unlikely that these two gene products catalyze SE formation, because the single deletion of ARE2 led to a more or less complete loss of SE.
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