Sentence examples for more complete knockdown from inspiring English sources

After an additional 48 h, the transfection process was repeated to achieve more complete knockdown.

Partial knockdown of Beclin 1 or haploinsufficiency does not limit the initiation of autophagy, although a more complete knockdown does [ 14].

For Fyn loss-of-function experiments, eggs were injected with 2.5 ng of a Morpholino, which targets both zebrafish fyn paralogs, fyna and fynb, to generate a more complete knockdown of Fyn function (Jopling and den Hertog, 2005).

It has been reported that SREBP RNAi decreases the size of RPE cells [ 26], but this observation may be due to the combined effects of AKT and hydroxytamoxifen (note that tamoxifen potently increases cell size) or to more complete knockdown because SREBP knockout mice are lethal.

The more complete PDF knockdown in the s-vLNs by Mai179-Gal4 walsolso accompanied by a measurable reduction in morning anticipation, but this reduction was not significantly different than one of the relevant control lines, casting doubt on the link between s-vLN PDF levels and morning anticipation.

Treating with Tet in combination of 3-MA or genetic knockdown of Beclin-1 leads to a more complete dual inhibition of both the induction stage and the degradation stage in autophagy.

Further characterization of these signals on the protein level will offer a more complete understanding of the cellular targets and pathways affected by knockdown of FAS and may lead to new therapeutic strategies for tumor prevention and treatment.

This example of incomplete knockout in mice versus comprehensive knockdown in zebrafish illustrates the utility of zebrafish for obtaining a more complete disruption of gene function in some cases.

To obtain a more complete picture of the composition of RUNX1 and RUNX1/ETO-associated transcription-factor complexes without RUNX1/ETO knockdown, we also analyzed publicly available data for the E box protein HEB (Martens et al., 2012; Ptasinska et al., 2012).

Since knockdown of MT1-MMP itself can affect invadopodium dynamics (Fig. 6), a more complete block of the pathway with ILK-KD might lead to the difference that we noted for invadopodium dynamics.

Although siRNA knockdown of the mitochondrial LON peptidase 1 partially restored TFAM and mitochondrial respiratory protein levels, the more complete reversal observed with U0126 implicate additional mechanisms, potentially related to protein synthesis.