For example, by taking into account differences in differentiation efficiencies, we can identify a more complete set of differentially expressed genes.
To gain a more complete understanding of population differentiation in the wild, we integrated evolutionary developmental biology with population genetics, morphology, paleoecology and ecology.
Perhaps more importantly, where a complete differentiation of parasites into stumpy forms could be achieved in the bloodstream, a trypanostatic response (stumpy formation) would inevitably lead to a trypanocidal outcome through the action of the immune response (45), clearing the infection.
Here we use an integrative approach that combines multiple levels of organization (gene networks, development, and phenotype) as well as multiple fields (population genetics, paleoecology and ecology, morphology, and evolutionary developmental biology) to gain a more complete understanding of population differentiation in the wild.
These recent finding cannot exclude the possibility that complete differentiation or maturation of differentiated cells require more specific factors.
Identification of new molecular drivers, as well as unbiased, more complete and clinically relevant mechanisms of RA-induced differentiation of NB is still a great challenge.
More analyses of these different chromatin modifications are required for a more complete understanding of gene priming, repression and activation during differentiation of these cells.
The transcriptomic analysis will help to identify gonad-specific/differential genes by comparing the transcripts in the testis and ovary libraries, which will help build a more complete understanding of the regulatory mechanisms associated with gonadal differentiation and reproductive processes.
In the future, it will be necessary to gain a more complete understanding of the role that cholesterol has during the differentiation and specification of red blood cells.
Simultaneously testing multiple Th lineages and drug concentrations allows a more complete characterization of the effects of a compound on Th differentiation and furthers mechanistic conclusions.
