Sentence examples for more complete blockade from inspiring English sources

Therefore, the combination of ACE inhibitors and angiotensin II receptor blockers (ARBs) has been propagated for more complete blockade of the renin-angiotensin system [10], [11].

Dual HER2 blockade is defined as a more complete blockade of the HER2 and HER signaling pathway by combining two inhibitors with complementary mechanisms of action.

Clinically, a more complete blockade of the HER receptor layer has been shown to be therapeutically meaningful in prolonging survival in patients.

In addition glomerular filtration rate (GFR) is a function of perfusion pressure and more complete blockade of angiotensin II could lead to excessive decreases in GFR thereby limiting the drug's utility in patients with chronic kidney disease.

Nevertheless, our girdle-shaped injection of less local anesthetic volume (5 ml on each side) may theoretically produce a more complete blockade of cutaneous nerves than a subcutaneous "bleb" of anesthetic solution.

Complete and sustained HER3 and/or HRG inhibition may, therefore, inhibit HER3-dependent resistance to EGFR inhibition and produce a more complete blockade of signaling from HER family members (Xia et al., 2005, Sergina et al., 2007).

These results suggest that a more complete RAAS blockade is not more beneficial, meaning that, regarding outcomes, the effects of combination therapy and ACE inhibitor monotherapy are comparable.

However, with a more complete HER2 blockade, resistance to L-containing regimens requires the activation of an alternative cell survival pathway.

More complete androgen blockade can be achieved by supplementing castration with anti-androgens such as flutamide, nilutamide, and bicalutamide, and such therapy is referred to as maximal androgen blockade (MAB) [ 24].

With more complete HER2 blockade, resistance to L-containing regimens required the activation of a redundant survival pathway, ER, which was up-regulated and promoted survival via various Bcl2 family members.

Furthermore, it is unclear whether more complete angiotensin II blockade will lead to clinically relevant incremental benefits.