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One of the more compelling studies described in the book involved trick-or-treaters.
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Smartphones could make a more compelling study.
More compelling are recent studies of a gain-of-function missense mutation in the L-type Ca2+ channel CaV1.2 that causes Timothy syndrome, which has a 60% rate of co-morbidity with autism (Splawski et al. 2004), making it one of the most penetrant monogenic forms of ASD.
Even more compelling, gene expression studies showed parallel expression changes between races of H. melpomene and H. erato in exon 13 of the kinesin gene and in-situ hybridization experiments suggest consistent spatial and temporal patterns of gene expression on the forewing [ 37].
That's more compelling that this study that says, "Hey, a few people who illegally download music actually buy more music than non-illgeal downloaders".
Even more compelling is a study done by Gary-Webb and colleagues [ 16] where combined known mediators, socioeconomic status and depression, and neighborhood characteristics were used to assess T2DM-related outcomes.
Comparative case studies may generate more compelling evidence than single case studies because they allow for the analysis of patterns between cases and the derivation of more robust results [ 32, 33].
Data on the link between smoking and RA are more compelling and include recent studies implicating a gene-environment interaction (see below).
As important, results will be more compelling if the ongoing studies have implemented successful strategies to ensure complete or near-complete follow-up and have paid careful attention to decisions regarding medical prophylaxis and optimising adherence in both arms of the study.
So, the more compelling interpretation of this study relates to its implications for immediately altering current clinical practice.
We understand that the evidence from multiple cases is often considered more compelling, and the overall study is therefore regarded as being more robust.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com