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FUS and TAF15 seem to have more compatible binding sites.
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The most noticeable movements occur in Phe89, Phe137 and Gly138 upon accommodation of D-Tyr3AA making the active site more compatible for substrate binding.
Although Tyr is not detectably incorporated into proteins when expression media is supplemented with 1 mM nitroTyr, a major difference between the first- and second-generation RSs is that the second-generation RSs have an active site more compatible with Tyr binding.
In contrast, compatible binding sites are more likely to lead to a difficult discrimination task.
The second possibility, and perhaps the more compatible with our data, is that the DNA-binding domain acts as a 'grip' that allows the enzyme to generate enough tension/force to move the nucleosome.
I considered motifs with a string of 6 or more compatible nucleotides, of which at least 5 are "preferred", as being capable of binding TBP with high affinity (+ motifs).
We find that the resulting single-point mutants have similar RNA binding affinities but exhibit significantly different ATP hydrolysis, transcription termination, and RNA DNA unwinding activities that are more compatible with the asymmetric Rho structure than with the 'trimer-of-dimers' structure and the resulting "handoff" model.
My spirit is more compatible with New York.
I found ancient cultures more interesting, more compatible and comforting".
Fidelity and scepticism are more compatible than you think.
It had been more compatible than Bertie's.
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