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The authors called for more comparative trials to increase their confidence in the findings (Fontanarosa et al. 2013).
More comparative trials are required to further assess the relative efficacy of the two agents.
Limited evidence indicates broadly similar efficacy and tolerability for topiramate 100 mg/day and propranolol 160 mg/day, though more comparative trials are required.
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In conclusion, more comparative effectiveness trials are needed for CLEWs, for which head-to-head comparisons are fewer than those for psoriasis and AV.
More comparative effectiveness trials are needed.
The new approaches hold great potential for efficiently selecting a more effective treatment in comparative trials.
Comparative trials are performed between the more common liposomal amphotericin B LAmBB) and amphotericin B colloidal dispersion (ABCD), which is less frequently studied.
Significant differences in the potency of these two drugs, vis-à-vis their degree of aromatase inhibition, have been observed in comparative trials and show that letrozole causes a more complete suppression of estrogen levels than does anastrozole.
Hence, whilst direct comparative trials are lacking, combined HT appears to be more effective at treating vasomotor symptoms than estrogen alone (Slowinska-Srzednicka et al 1992).
Comparative trials in patients with newly-diagnosed epilepsy makes it more difficult to obtain significant differences due to the high number of patients needed and the usually lengthy time course of the study.
However, there are no comparative trials to indicate that the 60 mg dose is more effective than the 40 mg dose.
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