Sentence examples for more compact chromatin from inspiring English sources

Cells with more compact chromatin were characterized by having larger clusters of chromatin.

This suggested to us that the combinatorial effect of differential histone modification load across gene bodies may result in an overall more compact chromatin configuration across exons of expressed genes.

Loss of histone acetylation leads to a more compact chromatin conformation and loss of transcriptional activity [40], and histone H3/lysine K4 methylation associates with active genes [41], [42].

From these studies, we conclude that a dispersed global chromatin architecture is characteristic of pluripotent cells and distinct from a more compact chromatin architecture formed in lineage-committed progenitor cells.

At the four-cell stage, both decondensed 10 nm nucleosomal chromatin fibres dispersed throughout the nucleoplasm (D Ch in Figure 3G,H) and blocks of more compact chromatin were prevalent, usually near the nuclear envelope but also in the nuclear interior (CCh in Figure 3C,G,H).

Several such chromatin fibres connect to a more compact chromatin patch.

Sites that were depleted in open chromatin sequences were considered to be regions of more compact (negative) chromatin.

In contrast to the permissive and accessible chromatin state found at most CGIs, polycomb mediated chromatin modifications are thought to generate a more compact and inhibitory chromatin environment, limiting transcription of associated genes (Shao et al., 1999; Lavigne et al., 2004; Francis et al., 2004; Eskeland et al., 2010).

H4K20me3 affects internucleosomal interactions resulting in more compact higher order chromatin structure [ 76].

Nucleosomes containing the histone H2A.Z variant, for example, compact chromatin fibers more readily than those with canonical H2A, and those with the macroH2A variant wrap DNA more stably, whereas nucleosomes substituted with another variant called H2A.Bbd (for Barr body deficient) do not allow chromatin to readily condense and wrap DNA much more poorly.

It is possible, that "open" chromatin structures are more easily dislocated than silent, compact chromatin structures.