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This behavior was expected for genes with small coding regions, which might be more commonly deleted than mutated [6].
The RB1 gene is more commonly deleted or mutated in castration-resistant prostate cancer (up to 45% of patients) than in clinically localised prostate cancer, and is coincident with the emergence of castrate-resistant disease (Taylor et al, 2010; Grasso et al, 2012).
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In the same study, two additional commonly deleted regions, localized more proximally along 18q, were identified [7].
It comprises more than 50 genes including the recently identified commonly deleted genes INHBA, GLI3, PGAM, and GCK.
Deletion mapping studies in OTs have revealed multiple commonly deleted regions on chromosome 1p, suggesting that there are more than one tumour suppressor gene.
Detailed deletion mapping revealed two distinct commonly deleted regions.
Detailed deletion mapping identified two independent commonly deleted regions on this chromosome arm.
Another deletion bias expected if RTMIL has commonly deleted introns is the frequent loss of adjacent introns.
We further selected candidate genes with typical promoter CGI and also located at important chromosome loci commonly deleted in tumours and possibly harbouring putative TSGs for more detailed studies, such as DLEC1.
By comparing overlapping chromosome 5 deletions among patients with del 5q) MDS, two commonly deleted regions (CDRs) have been identified.
Fine mapping localized a commonly deleted 78 kb region that contains three genes: SCRIB, NRBP2, and PUF60.
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