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Insofar as three of the more common haplotypes a g were absent from another study [17] our data may yet underestimate the full extent of diversity in SPRN, lending further support to the main conclusion of this paper.
People of European descent, Hispanics and Indians have more common haplotypes.
The more common haplotypes were found in many (up to 31) different thelytokous MLGs.
Fewer rare and more common haplotypes would occur than in actual populations with unbalanced contributions to the next generation.
Fst analysis in Turbo samples supports the theory of re-infection by the more common haplotypes, instead of relapse during the recurrence events.
Therefore, we expect that this ROH type would be on average shorter, composed of more common haplotypes, be concentrated in fewer genomic locations, and contain fewer deleterious alleles than the genomic average.
Similar(54)
At the molecular level, we recently characterized the role of this haplotype in influencing the expression of SAT1, and found that the more common haplotype was associated with lower gene expression in vitro and in the brain [31].
It is important to note that the H1 haplotype is the more common haplotype in all populations, and thus associations of a common haplotype with a rare trait become more challenging statistically.
The MAPT gene is localized on chromosome 17q21 and is represented by two haplotype clades, the more common H1 haplotype and the rarer H2 haplotype, which result from a large (∼970 kb) chromosomal inversion (Stefansson et al., 2005).
Finally, the patterns of haplotype divergence found in our study are also consistent with recent lineage formation, sharing is largely restricted to the more common central haplotypes.
The majority of ongoing studies have focused upon targeting more common MHC haplotypes, however, for widespread application numerous TCR combinations for specific target antigens will have to be developed and validated.
More suggestions(15)
more reliable haplotypes
more resistant haplotypes
more overlapping haplotypes
more divergent haplotypes
more diverse haplotypes
more significant haplotypes
more distant haplotypes
more accurate haplotypes
more local haplotypes
more homologous haplotypes
more similar haplotypes
more underlying haplotypes
more different haplotypes
more common ones
more ancestral haplotypes
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