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In addition, 9p23 and 15q24.1 were found to be more common gains in N0 and losses in N1-3 type gastric cancers.
Loss events are approximately 2.1-fold more common than gain events, but have smaller sizes than gain events on average (28.5 kb vs. 37.6 kb).
Loss events are approximately 1.7-fold more common than gain events, but have slightly smaller sizes than gain regions on average.
Loss events were approximately 2.65-fold more common than gain events, but slightly smaller than the size of gain regions on average (45.48 kb vs. 80.00 kb).
This is not surprising, as it is easier to predict a more common event (gain of ≥ 5 kg) than a less common one (gain of ≥ 10 kg).
Additionally, intron loss appears to be more common than gain throughout eukaryotic evolution.
Concerning copy number status, loss events were approximately 2.65-fold more common than gain events in CNVRs.
Loss events are approximately 6.2-fold more common than gain events in CNVRs, while the corresponding rate is 2.5-fold for CNVs.
In general, deletions were more common than gains and no high-level amplification was found, supporting previous findings of primarily losses of large chromosomal regions as an important mechanism in chordoma development.
For all the detected CNVs, losses were more common than gains, with the ratio ranging from 7-to-1 to 2-to-1.
We found that intron loss events are at least two orders of magnitude more common than gains.
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