Other gene variants have become less common, the researchers say, like the gene for sickle cell hemoglobin, which in its more common single-dose form protects against malaria.
This adverse effect is found to be related to dose used and is more common at higher doses [ 33].
Objective: The objective of the study was to evaluate the efficacy of gentamicin and clindamycin given once daily versus the more common 8-hour dosing regimen for the treatment of postpartum endometritis.
As research in non-clinical populations becomes more common, disparity in dosing protocols and clinical endpoints will likely continue to cause conflicting findings.
As research in nonclinical populations becomes more common, disparity in dosing protocols and clinical endpoints will likely continue to cause conflicting findings.
Although response rates and survival were similar, toxicity was more common in the dose-intense group than in the standard dose group (McGuire et al, 1995).
Generally, to increase the AUC0 24, increasing the dose (e.g. IV 400 mg to 600 mg) or the frequency of dose (12-hourly to 8-hourly) are the more common methods for dose adaptation.
The former two symptoms were observed more commonly with low doses of liposomal irinotecan, and the latter two symptoms were more common with high doses of liposomal irinotecan [64, 68].
67 68 69 70 In addition, risk factors for fractures and comorbidities were more common among low dose levothyroxine users, which would argue against a selection bias explaining the association between high dose levothyroxine and fractures.
Treatment-related AEs were more common in the dose-escalation and the non-randomised grade ⩾2 rash arms (both 100%) compared with the standard-dose arm (87%).
