Sentence examples for more committed progenitors from inspiring English sources
By a combination of fractionation and in vivo reconstitution, studies have identified cell surface markers that differentiate freshly isolated HSCs from more committed progenitors in both humans and mice [7].
These normally more committed progenitors can thus acquire self-renewal properties.
There is also ample evidence that it may have a pro-differentiation effect on more committed progenitors.
The most primitive haematopoietic progenitors in human bone marrow express the stem cell factor receptor c-Kit at low levels compared to more committed progenitors (Gunji et al, 1993; Katayama et al, 1993; Doi et al, 1997; Lian et al, 1997).
Similar results were previously demonstrated when MLL-ENL was expressed in HSC with the efficiency of transplantation being HSC> common myeloid progenitor (CMP) >GMP, indicating that the more primitive populations required fewer cells for transformation with more committed progenitors still retaining this capacity [ 5].
These cells have the ability to divide throughout the lifespan of the organism to give rise to more committed progenitor cells generating a large number of undifferentiated cells.
But also more committed progenitor cells (CD34+CD38− and CD34−) and even peripheral blood mononuclear cells (PBMCs) revealed elevated foci levels compared to the cord blood derived subtypes (Fig. 4, upper panel).
CFU-G and CFU-M represent more committed progenitor cells with a more restricted potential to differentiate.
Based on these results, the population of Ncam1+ cells likely was heterogeneous, comprising a mix of stem and more committed progenitor cells.
This is somewhat unexpected because BC subtypes have been linked to the cell-of-origin within the mammary epithelial cell hierarchy; claudin-low tumors are thought to arise from transformation of mammary stem cells, basal-like tumors from bi-potent/early luminal progenitors, HER2+ BC from more committed luminal progenitors, etc. (Lim et al, 2009; Prat & Perou, 2009).
This is likely the result of continued high Nestin expression in more committed neural progenitors as well as a potential lag in the mCherry expression compared to endogenous Nestin that is a result of their differing protein stabilities.
