Sentence examples for more committed cells from inspiring English sources

In acute lymphoblastic leukemia (ALL) leukemia initiating cells (LICs) have been considered to be organized in an hierarchical fashion, however recent findings demonstrated LIC-activity also in more committed cells supporting a stochastic stem cell concept.

Therefore we postulated CD34+ cells give rise to more committed cells while tightly maintaining the parent population during the course of regeneration.

The stem cell niche governs asymmetric cell division of two daughter cells that may either self-renew to replenish the stem cell pool or to differentiate to more committed cells.

Moreover, the H3K27me3 histone mark has been found at the Oct4 promoter in more committed cells, suggesting that PcG proteins are involved in direct repression of stem cell regulators in differentiated cells [28].

That seems to hold true in both stem cell self-renewal and differentiation of more committed cells.

In the mouse, we observed that loss of Bmi1 reduces mammary stem cell activity, but Bmi1 is also required for the proliferation of more committed cells [ 22].

To determine the specificity of mCherry to NSCs or NPCs compared to more committed cell lineages, we used cell surface markers that highlight these different neural subpopulations.

Stem cells had more bivalent genes than the more committed cell types, but several genes developed bivalency in downstream cell types.

For example, our study has focussed on ESCs where polycomb factors are highly abundant, so it will be imperative to understand if similar KDM2B dependent PRC1 targeting mechanisms function in more committed cell types.

For example, our study has focussed on ESCs where polycomb factors are highly abundant, so it will be imperative to understand if similar KDM2B dependent PRC1 targeting mechanisms function in more committed cell types.' * What excludes KDM2A from Polycomb target CGIs?

Initially, we predicted that similar to the hematopoietic system, a linear relationship existed within the satellite cell compartment of skeletal muscle, where more primitive CD34− cells give rise to more committed CD34+ cells.