Your English writing platform
Discover LudwigSuggestions(1)
Exact(2)
We observed that although parental cells migrate primarily individually (i.e. as little groups of cells or as individuals), SNAI1 blockade resulted in a more collective migration phenotype.
Taken together these results suggest that SNAI1 functional blockade is leading to partial re-expression of E-cadherin (i.e. at the level of transcription), to a decrease in PAI-1 and to a more collective migration, while the parental cells expressing SNAI1 have less E-cadherin, more PAI 1, and migrate individually.
Similar(58)
Lalli & Asthagiri showed, using densely-packed 2D cultures of mammary epithelial cells, that collective migration was more sensitive to dcEF (responding to 50% weaker fields than dispersed cells), yet the resulting electrotactic alignment occurred with slower dynamics29.
Density plays a major role in collective migration: denser cells move slower but more coordinately (e.g., in refs [ 4, 5].
In SNAI1-DN cells, cell migration is quantitatively decreased, and this is associated with morphological changes with SNAI1-DN cells displaying a more collective behaviour compared with MDA-mock cells that tend to migrate individually.
Tumor cells may migrate in bulk as clusters, strands, or sheets (collective migration) or individually.
The finding of both individual CTCs and, more rarely, CTM in pancreatic cancer patients raises questions regarding the mechanisms of cell migration and extravasation, evoking the possibility of collective migration where cells maintain their contacts to invade (Friedl and Wolf, 2003).
CAFs lead collective migration of cancer cells in 2D.
There was no signal, not much discussion — just a collective migration.
Lebreton, G. & Casanova, J. Specification of leading and trailing cell features during collective migration in the Drosophila trachea.
Arboleda-Estudillo, Y. et al. Movement directionality in collective migration of germ layer progenitors.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com