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Finally, diagnostic procedures may be more clinically valid when conducted in a clinical setting.
A more clinically valid classification of this pre-dementia state may be Aging-Associated Cognitive Decline (AACD; [ 32]), which has clearly defined diagnostic criteria and requires impairment in multiple cognitive domains [ 30, 31].
We therefore expected the results on HDRS to be a more clinically valid compared to the BDI results—but we cannot exclude that breaking of blinding and biased assessment of the HDRS may have occurred.
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"I think we're moving from a SNP world where the associations are weak and questionable, to a whole genome world where there will be more strong and clinically valid associations," says Greely.
By projecting the data over 10 and 20 years, the authors hypothesized that because the model would produce "real cost-effectiveness results in terms of cost per EDSS month of disability prevented", it may be more "valid and more clinically meaningful than cost-utility ratios".
However, HDRS might not at all be a clinically relevant outcome and other more clinically relevant outcomes might be more valid to use in future trials.
A more generic, less detailed but no less clinically valid impression of patient frailty has also been developed by Rockwood and colleagues [ 1].
These findings provide evidence that the RLSQoL is clinically valid in this clinical trial population.
This study presents a research framework for developing culturally and clinically valid, reliable measures of clinical practice.
Whilst HOMA-IR may be considered more statistically valid, the use of IR as a binary variable is more clinically useful and so both outcomes are presented here, with results that were consistent using both approaches.
There are well-documented problems with conducting valid randomised trials in this area, and it may be that for some questions more, and more clinically relevant, information can be obtained from other types of primary study, such as large registry studies.
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CEO of Professional Science Editing for Scientists @ prosciediting.com