It is important to evaluate emerging imaging biomarkers of primary and metastatic breast cancer and there is a requirement for new, more specific and clinically translatable radiotracers for positron emission tomography/single-photon emission computed tomography (PET/SPECT) [ 401, 402].
However, the disappointment of negative results must be weighed against the benefit of being able to refocus efforts on drugs, which are more likely to be clinically translatable.
To assess whether this observation was translatable into more clinically relevant in vivo results, mice bearing subcutaneous tumors were injected intratumorally either with virus or with virus mixed with heated serum.
Since metastatic NB has a high mortality rate, understanding the molecular mechanism flow-through that is involved in neuroblastoma cell invasion and metastasis will help us to design more effective therapies against metastatic NB, particularly when we use appropriate clinically translatable animal models.
These were successfully evaluated noninvasively with PET, a widely used clinical imaging technique in oncology, which is quantitative, sensitive, and clinically translatable.
Because many different cancer types share similar tumor microenvironment features, the ability to target these biomarkers has the potential to provide clinically translatable molecular imaging technologies for a spectrum of cancers and broad clinical applications.
This study indicates that a clinically translatable strategy of engineering the DC content of grafts can improve clinical outcomes in allogeneic HSCT through the regulation of donor T cell activation and GVL activity.
These SF solution properties can be tuned/designed/engineered to achieve biomaterial scaffolds for clinically translatable applications of reconstruction and repair of defects in cancer patients per clinical and patient-specific need.
The study also proved that caseload midwifery is more clinically effective.
The more clinically focused applications tend to lead to quicker but less fundamental breakthroughs.
