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Hopefully, these lessons may serve as a building block whose incorporation in the design of second-generation trials will help making them more clinically successful.
One of the more clinically successful implant surface modifications in recent years was the chemical modification of the sandblasted, large-grit, acid-etched (SLA) surface to produce the hydrophilic SLActive® surface (Straumann AG, Basel, Switzerland).
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However, the bone ingrowth into the new surface structures appears to be comparable to more conventionally made surfaces of clinically successful implants at 6 weeks after surgery.
Additionally, targeting individual cytokines alone has not been clinically successful, but a more pluripotent approach such as is offered by A2A AR agonists may be more successful.
Two of the most clinically successful and intensively studied technologies that operate at the nanoscale are "stealth" and "targeted" medicines.
The study also proved that caseload midwifery is more clinically effective.
The more clinically focused applications tend to lead to quicker but less fundamental breakthroughs.
Her friend Danielle Goodlow, 22, a surgical coordinator for a Beverly Hills plastic surgeon, looked over the competition more clinically.
Eleanor Laws QC, prosecuting, dismantled his character more clinically than any Coronation Street scriptwriter could possibly have done.
"As the numbers go up along the Eastern Seaboard, all coastal communities could face more clinically significant stings," Yanagihara said.
In contrast, He et al. [8] reported clinically successful outcome of immediate re-insertion of a wider implant when the previous implantation was a failure, and Nelissen et al. [9] reported that implants of 4.5 mm in diameter were more stable than those of 3.75 mm in diameter and brought about clinically favorable effects in a short period (6 months) of follow-up.
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