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Patients prescribed combination therapy at baseline were more clinically severe, were more often treated as inpatients and had more manic episodes in the previous year compared with the monotherapy group.
Horsthuis et al. [42] performed the first studies using these types of sequences and observed that greater numbers of pixels were rapidly enhanced in patients with more clinically severe disease, although they did not observe a correlation between the semiquantitative parameters and the perianal disease activity index.
The disease reportedly was much more clinically severe than it had been in 1943 (16 ).
For each item, the points range from 0 to 2, where higher values represent more clinically severe symptoms.
Consistent with most prior findings in European and US populations, we find that melancholia is a more clinically severe syndrome than nonmelancholic depression with higher rates of comorbidity.
The effect is more pronounced in MSF, which is also normally the more clinically severe rickettsiosis of the two, and only in ATBF did both chemokines approach levels similar to controls in the reconvalescence phase.
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Blood cultures were performed at clinician discretion and not necessarily for all patients with possible sepsis or meningitis, possibly resulting in missed cases or biasing our study toward the more clinically apparent or severe cases.
Thus, more clinically relevant and severe models of cardiac arrest, that is, with an underlying acute myocardial ischemia, a condition present in more than 70% of cardiac arrest events, are presented, together with investigations on the role of progressive mitochondrial ischemia during cardiac arrest and a focus on the quality of chest compression as determinant of resuscitation [ 7, 8].
Thus, the combination of anemia and CKD could interact to make a stroke event more likely to occur or more likely to be clinically severe [ 6].
If this is the case, the higher incidence of HP eradication associated with diabetes (Tables 2 3 4) may implicate that HP infection in the diabetic patients is more clinically active with more severe symptoms, leading to its diagnosis and the use of medications for its eradication.
Thus it may be less pejorative and more clinically useful to conceptualise hypochondriasis as severe and persistent health anxiety, lying at the far end of a continuum that has mild health anxiety at its other end.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com