Exact(3)
The dominant types of OP are more clinically challenging because of normal life expectancy in comparison with recessive (malignant) forms [1, 3, 17, 35, 36].
Taken together, these aspects turn phase I and II research into scientifically challenging studies (in contrast to more clinically challenging phase III studies; see box).
At many centers, PET is carried out in the more clinically challenging cases, such as the difficult-to-biopsy lesions (e.g. patients with severe emphysema), or in patients who are at greater than usual risk at surgical assessment/biopsy.
Similar(57)
Two major clinical entities of periodontitis are currently recognized: chronic periodontitis, which is more common, and aggressive periodontitis, a clinically challenging entity featured by an early onset and a rapid progression [ 5].
Since fewer autopsies are performed, clinically challenging cases may be more likely to be selected for autopsy.
Diagnosis of constrictive pericarditis remains clinically challenging.
Repairing articular cartilage is clinically challenging.
The regeneration of hyaline cartilage remains clinically challenging.
The regeneration of large bone defects remains clinically challenging.
A proper diagnosis and the correct therapeutic approach therefore remain clinically challenging.
STSs are clinically challenging to manage.
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