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It is unclear if this histologic observation translates into more clinically aggressive tumors.
Among TETs, thymoma is the most predominant, characterized by a unique association with autoimmune diseases, followed by thymic carcinoma, which is less common but more clinically aggressive.
The presence of heterologous elements, especially rhabdomyosarcoma, may represent a more clinically aggressive tumor.
Taken together, in ER+ tumours low YAP1 expression is linked to more clinically aggressive features including grade and proliferation.
Moreover, studies with larger cohort size are warranted to assess our finding in familial breast tumours, that the genome of high-grade luminal A tumours had significantly less CNV coverage than the more clinically aggressive high-grade luminal B tumours.
The more clinically aggressive form is SCC of the skin [ 2], which has been increasing in incidence since the 1960 s at annual rates from 4% to as much as 10% in recent years.
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Notably, when compared with serum PSA, serum Cav-1 more specifically identifies clinically aggressive disease.
Whereas DLBCL is a clinically aggressive disease for which incidence increases with age, FL and SLL/CLL present a more indolent clinical course.
Thereby, the fact that eugenol can inhibit both E2F1 and survivin in vitro and in tumor xenografts, indicates that eugenol could be used to consolidate the adjuvant treatment of breast cancer patients, especially the clinically aggressive ER-negative types, whose prognosis is still poor and clinically characterized as more aggressive and less responsive to standard treatments [ 30, 31].
More importantly, the aberrant expression of GOLPH3 in these cancers has been indicated to be correlated with clinically aggressive behaviour and patient survival.
ADC values cannot distinguish between clinically stable and clinically aggressive ONG.
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