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The failure to obtain more clear cut differences, despite being based on 68 patients, is due to the high SD (± 0.22) of KI (2 7), which seems to arise from heterogeneity of kill rates early in treatment (Fig 1).
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Compared to the LSO/MNTB ratio a much more clear cut difference was revealed for the ratio of LSO to MSO for chimpanzee, bonobo and man (1.1) compared to gorilla, orangutan, gibbon and macaque (≥1.5; Table 1).
The strategy we pursued instead was to upgrade both models (by adding one additional parameter to each), and to investigate whether a more clear-cut difference emerged when we compared the upgraded models.
Since spontaneous healing probably accounts for the absence of improvement in the percentage of new cartilage area in the MSC group relative to the gel group, another study design using larger defects, e.g. 5 mm in diameter, might result in a more clear-cut difference in the degree of new cartilage between the MSC group and the gel group.
Catches might seem more clear cut.
The matter of lungs are a little more clear cut.
"This is much more clear cut".
The issue may be more clear cut for accounting firms.
The sending-off decision was even more clear cut.
I'm guessing your role on "Sesame Street" is a little more clear cut.
The decision for Tottenham's equaliser was more clear cut.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com