In patients with DM, reasons for admission were more often circulatory, metabolic, and infectious (p < 0.01).
Patients with hyperlactatemia plus low ScvO2, or high P(cv-a CO2, cv-a CO2CRT values exhibited a more severe circulatory dysfunction.
Patients with hyperlactatemia associated with either low ScvO2, or high P(cv-a CO2, cv-a CO2CRT values exhibit a more severe circulatory dysfunction.
Patients with hyperlactatemia plus low ScvO2, or high P(cv-a CO2, cv-a CO2CRT values exhibit a more severe circulatory dysfunction withighCRTased morbidity.
Higher mean dose of vasopressors administered to non-survivors may reflect the presence of a more severe circulatory failure with profound vasoplegia, which has long been related to unfavorable outcome [7].
Although lactate values at baseline (4.8 ± 2.8 vs. 4.7 ± 3.7 mmol/L) were comparable, the hypoperfusion-context subgroup presented a more severe circulatory dysfunction as expressed by higher NE requirements and a trend to a worse SOFA score (Table 1).
Although lactate values were comparable at baseline (4.8 ± 2.8 vs. 4.7 ± 3.7 mmol/L), patients with a hypoperfusion context exhibited a more severe circulatory dysfunction with higher vasopressor requirements, and a trend to longer mechanical ventilation days, ICU stay, and more rescue therapies.
Regarding main outcomes, patients with a hypoperfusion context exhibited a more severe circulatory dysfunction requiring higher NE doses at 6 h, and tended to have longer duration of mechanical ventilation, and higher use of HVHF as rescue therapy, in addition to longer ICU and hospital stays (Fig. 1).
The FloTrac/Vigileo system has yet to be shown to cope with more extreme circulatory conditions.
Towards this goal a UK bioengineering group is working to develop more affordable circulatory support devices.
