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Therefore, as more changes accumulate in a branch that defines a group in the species tree, more of the individual orthologous gene trees will reflect this group.
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Thus, differences in the allelic loss and mutation patterns have been reported previously between squamous and adenocarcinomas, suggesting that more genetic changes accumulate during tumorigenesis in squamous cell carcinomas than in adenocarcinomas (Sato et al, 1994).
It remains to be seen, however, whether the rate of change is indeed constant, or whether instead a non-linear model could more accurately reflect how changes accumulate with age.
Over time, these genetic changes accumulate and can make cells more prone to the skin cancer melanoma.
The observations of more genetic aberrations in metastases compared to primary tumors indicate that genetic changes accumulate during tumor progression.
The years and changes accumulate.
For example, do epigenetic changes accumulate with phylogenetic distance?
Approaches that target reductions in sedentary behavior and/or increases in standing or light-intensity physical activity [LPA] may not interfere with productivity and may be more feasible to achieve through small changes accumulated throughout the workday.
We would expect at least some level of similarity of biological networks between species; but the more distantly related two organisms are, the more changes can have accumulated in their respective molecular networks.
Additionally, conversions other than C-to-U in Vitis and other plants suggest that chloroplast genomes may be accumulating a considerable number of nucleotide substitutions, and some genes might accumulate more changes than others, such as the petL and ndh genes that have a high frequency of RNA editing [ 60].
As the costs of climate change accumulate, affluent nations and neighborhoods will have far more resources to defend themselves than poor ones.
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