However, given the continued decrease of the birth rate, the acceleration of aging in the population and the intensified population flow, the number of elderly-only families is rapidly increasing, and they are finding it more challenging to defend themselves against structural pressure during China's reforms.
While it may be easy to dismiss as trivial the structural basis for aberrant intermolecular thiol attack by MIDY mutants that add or remove a cysteine (Fig. 2), it is more challenging to obtain data providing structural evidence for why non-cysteinyl proinsulin mutants are also predisposed to form aberrant disulfide-linked protein complexes in vivo (Fig. 1).
The coordination that occurs between two heads in a kinesin dimer is even more challenging to explain with existing structural models.
However, the identification of new proteins involved in its structural organisation is a more challenging task, because it requires microscopy-based assays that are much more laborious.
Analysts at RBC Capital Markets said they were concerned about the longer-term outlook for H&M's like-for-like sales, "due to more challenging markets, increased price competition and a lower structural boost now from the rollout of online sales".
Structural design of composite shells are more challenging than conventional metals due to the complex mechanical behavior and damage mechanisms which composite materials exhibit.
Unlike hydrolytic sites, redox sites are more challenging to design as one must account for the structural changes associated with changing metal oxidation states.
Nevertheless, structural variation remains less understood and more challenging to detect and characterize than SNVs and smaller indels, both across populations and in personal genomes.
While BP clearly has considerable work to do to regain the trust of regulators, investors and the public – and could still face substantial legal and compensation bills – managing a business in structural decline like HMV could be far more challenging.
We first used a specific but highly challenging structural set [30], [31], and then a more comprehensive benchmark [32].
