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Tiled images of H&E sections were used as guide maps for more challenging specimens.
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In those specimens, identification was a bit more challenging, but the presence of calcareous corpuscles in the somatic matrix was particularly helpful in establishing that the organism was a larval tapeworm.
Registration of one specimen (#06 12) was found to be more challenging due to an old cerebral infarction.
Cases 32, 34 and 41 were vasectomy specimens that were removed before the study began and replaced by more challenging cases (chosen at random).
Demonstrating IL-1β cleavage by caspase-1 in biologic specimens is difficult, while demonstrating increased activity of the inflammasome is even more challenging [ 43].
If sequencing is done directly from clinical specimens (without previous culture), single virus sequencing could be achieved by limiting dilution PCR, although this is more challenging in view of low levels of target RNA.
"It is more challenging".
— to executing more challenging tasks.
Plastic corks are no more challenging.
More challenging to write?
This is a more challenging area".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com